Home Chemistry Heterocyclic Building Blocks Pyrans Spiro[Chromane-2,4'-Piperidin]-4-One
Reductive Amination: You can perform reductive amination by reacting the ketone group of spiro[chromane-2,4'-piperidin]-4-one with an amine in the presence of a reducing agent like sodium cyanoborohydride. This can lead to the formation of secondary or tertiary amines.
Nucleophilic Addition: The ketone functionality can undergo nucleophilic addition reactions with nucleophiles like Grignard reagents, organolithium compounds, or hydride sources. This can lead to the formation of alcohol or other functionalized products.
Acylation: You can react spiro[chromane-2,4'-piperidin]-4-one with acylating agents like acyl chlorides or anhydrides to introduce an acyl group. This can lead to the formation of acyl derivatives.
Reduction: The ketone group can be reduced using reducing agents like sodium borohydride or lithium aluminum hydride to form a corresponding alcohol.
Nucleophilic Substitution: If there are halogens or other leaving groups attached to the molecule, you can perform nucleophilic substitution reactions with various nucleophiles.
Ring-opening reactions: The piperidinone ring in the molecule can undergo ring-opening reactions under suitable conditions, leading to the formation of open-chain compounds.
Cyclization reactions: Depending on the conditions and reagents used, you may be able to promote cyclization reactions to form different cyclic compounds.
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Spiro[chroman-2,4'-piperidin]-4-one hydrochloride
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6-Bromospiro[chroman-2,4'-piperidin]-4-one hydrochloride
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tert-Butyl 4-oxospiro[chroman-2,4'-piperidine]-1'-carboxylate
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1'-(tert-Butoxycarbonyl)-4-oxospiro[chroman-2,4'-piperidine]-7-carboxylic acid
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tert-Butyl 6-bromo-4-oxospiro[chroman-2,4'-piperidine]-1'-carboxylate
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6-Bromospiro[chroman-2,4'-piperidin]-4-one
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